Simian virus 40 inhibits differentiation and maturation of rhesus macaque DC-SIGN+-dendritic cells

Simian virus 40 inhibits differentiation and maturation of rhesus macaque DC-SIGN+-dendritic cells

Blog Article

Abstract Dendritic cells (DC) are the initiators and modulators of the immune responses.Some a&d ej-123 species of pathogenic microorganisms have developed immune evasion strategies by controlling antigen presentation function of DC.Simian virus 40 (SV40) is a DNA tumor virus of rhesus monkey origin.

It can induce cell transformation and tumorigenesis in many vertebrate species, but often causes no visible effects and persists as a latent infection in rhesus monkeys under natural conditions.To investigate the interaction between SV40 and rhesus monkey DC, rhesus monkey peripheral blood monocyte-derived DC were induced using recombinant human Interleukin-4 (rhIL-4) and infective SV40, the phenotype and function verona wig of DC-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN)+ DC were analyzed by flow cytometry (FCM) and mixed lymphocyte reaction (MLR).Results showed that SV40 can down-regulate the expression of CD83 and CD86 on DC and impair DC-induced activation of T cell proliferation.

These findings suggest that SV40 might also cause immune suppression by influencing differentiation and maturation of DC.